Author

B. Polegato

2 papers indexed here

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Open access Oct 2026

Effects of SGLT2 inhibition on cardiac remodeling and heart failure development in aortic stenosis rats

Aortic stenosis (AS) is increasingly prevalent in ageing populations, yet no pharmacological therapy has been shown to modify its progression to heart failure (HF). Sodium glucose cotransporter 2 (SGLT2) inhibitors improve outcomes in HF, but their effects in pressure overload-induced cardiac remodeling remain unclear....

L. Pagan, M. J. Gomes, M. Gatto et al. · Molecular Biomedicine · 0 citations

Open access Aug 2026

Influence of sex and time on cardiac remodeling induced by vitamin d supplementation

Vitamin D (VitD) exerts diverse biological effects, including on cardiac function, with a biphasic dose–response profile. The growing use of high-dose supplementation has raised concerns, as excessive VitD, even without hypercalcemia. However, the timing of these effects and the influence of biological sex remain uncle...

M. Callegari, P. D. dos Santos, M. G. Monte et al. · Nutrire · 0 citations