Rewriting the brain: m6A RNA methylation as an emerging epitranscriptomic regulator in major depressive disorder
The dynamic regulation of m6A RNA methylation in the brain is summarized, its neurobiological functions are discussed, its potential role in stress-related pathology and MDD is critically evaluated, and m6A modification may represent a plausible epitranscriptomic mechanism governing synaptic plasticity in the depressed...