B. Schermer

Cell-type-specific damage scores reveal kidney and liver disease trajectories in single-cell and spatial transcriptomics.

Degenerative diseases progress through gradual cell-intrinsic damage that is difficult to resolve with bulk transcriptomics or discrete cell-state analysis. We introduce a generalizable single-cell and spatial transcriptomics framework that quantifies continuous damage trajectories in vivo using cell-type-specific scor...