ANALYTICAL QUALITY BY DESIGN-ASSISTED DEVELOPMENT AND VALIDATION OF A RAPID STABILITY-INDICATING GRADIENT ULTRA-PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR SIMULTANEOUS ESTIMATION OF EMPAGLIFLOZIN, SACUBITRIL, AND VALSARTAN IN PHARMACEUTICAL DOSAGE FORMS
Objectives: Simultaneous estimation of empagliflozin, sacubitril, and valsartan in combined pharmaceutical formulations is analytically challenging due to their differing polarity, physicochemical properties, and chromatographic retention behavior. Conventional high-performance liquid chromatography methods often requi...