Author

B. Srinivasan

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Open access Sep 2026

The human metabolite–protein interactome reveals a global layer of cellular coordination

Metabolites are substrates, products, cofactors, and regulators, but protein–protein interaction networks do not represent their potential to organize proteins across conventional pathway boundaries. Using the LIGMAP virtual-screening algorithm, we mapped 308 human metabolite codes to pockets in monomers, dimer interfa...

J. Skolnick, B. Srinivasan · bioRxiv · 0 citations

Review Open access Jul 2026

Expanding the landscape of covalent drug discovery: irreversible targeting of non-cysteine residues.

Covalent inhibitors have re-emerged as a powerful class of therapeutics due to their prolonged target engagement, ability to decouple pharmacokinetic availability from pharmacodynamic outcome, potential for high selectivity and ability to modulate traditionally 'undruggable' targets. Historically, cysteine residues hav...

B. Srinivasan, John B Taylor · British Journal of Pharmacol... · 0 citations