Chronological age is a dominant determinant of cardiovascular risk prediction. However, DNA methylation-derived epigenetic clocks capture biological aging processes that may reflect cumulative cardiometabolic and inflammatory exposures. Whether biological age improves contemporary cardiovascular risk estimation,...
R. Ibrahim, B. Tamarappoo, K. Lee et al.· European Heart Journal· 0 citations
AIMS
Among women with suspected ischaemia and non-obstructive coronary artery disease (INOCA), the temporal effect of combination intensive medical treatment (IMT) with angiotensin-converting enzyme inhibitors or receptor blockers, statins, and aspirin on coronary plaque composition is not known. This prospective ancil...
J. Lenell, Guadalupe Flores Tomasino, Donghee Han et al.· Cardiovascular Research· 0 citations
Background: Epigenetic clocks derived from DNA methylation estimate biological aging and have been associated with cardiometabolic death. We evaluated whether substituting epigenetic age for chronologic age within PREVENT altered associations with all-cause and cardiovascular mortality or improved discrimination. Metho...
Ramzi Ibrahim, B. Tamarappoo, Kwan S. Lee et al.· Circulation. Population heal...· 0 citations
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