Immunotherapy has created new opportunities for treating triple‐negative breast cancer (TNBC), but its benefit is often limited by an immunosuppressive tumor microenvironment. Here, we report BMFL, a folate receptor‐targeted liposomal nanoplatform that co‐delivers a near‐infrared aggregation‐induced emission luminogens...
Wen-Kai Zhang, Xue-Ke Yan, Xiepeng Deng et al.· Aggregate· 0 citations
Triple-negative breast cancer (TNBC) remains a formidable clinical challenge owing to its aggressive metastatic behavior and the absence of well-defined therapeutic molecular targets. Although photodynamic therapy (PDT) holds immense promise, its efficacy is often limited by the aggregation-caused quenching (ACQ) of co...
The intratumoral microbiota acts as a microbial immune checkpoint in colorectal cancer (CRC), yet current strategies either kill silently without immune activation or permit bacterial rebound through incomplete targeting. Here we report a bio-hybrid assembly designed to synchronize the eradication of CRC cells and thei...
Maliang Tao, Bin-Bin Wei, Yen-Yu Yang et al.· Advances in Materials· 0 citations
This study overcomes the intrinsic trade-off between radiative and non-radiative decay pathways in aggregation-induced emission luminogens (AIEgens) for phototheranostic applications and enables effective imaging-guided eradication of MRSA in back and joint abscess models.
Qi-Cheng Zhang, Jian Zhang, Lei Ye et al.· Acta Biomaterialia· 0 citations
Photodynamic therapy (PDT) faces significant challenges in treating solid tumors due to the hypoxic tumor microenvironment and high degree of tumor heterogeneity. To address this issue, this study employed a strategy of acceptor planarization coupled with tunable terminal aryl modulation to design and synthesize a seri...
Xuemei Dong, Lingan Zeng, Yunlong Liu et al.· Advanced Healthcare Material...· 1 citation
The clinical efficacy of photodynamic therapy (PDT) is fundamentally limited by the scarcity of efficient photosensitizers (PSs) and the oxygen dependence of singlet‐oxygen–mediated cytotoxicity. Here we report pentaperylene decaimide selenide (PPD‐Se), a nanographene‐derived photoelectronic material that functions as...
Gong-Cheng Ma, Nan Zhang, Hongrong Shi et al.· Advanced Healthcare Material...· 1 citation
In an era marked by increasing demand for advanced anticounterfeiting measures, we introduce a four-dimensional (4D) dynamic physical unclonable function that uses defect-engineered photoluminescence blinking in all-inorganic CsPbBr3 perovskite quantum dots (QDs) embedded within a polymethylmethacrylate matrix. Even wi...
