Highly Diastereoselective Synthesis of Trifluoromethylated Spirocyclopropanes from 2-(2'-Ketoalkyl)-1,3-Indandiones and CF3-Imidoyl Sulfoxonium Ylides.
A metal-free and highly diastereoselective strategy for the synthesis of trifluoromethylated spirocyclopropanes has been developed using CF3-imidoyl sulfoxonium ylides (TFISYs) and 2-(2'-ketoalkyl)-1,3-indandiones. The transformation proceeds through a base-mediated cascade process to furnish densely functionalized tri...