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Author

B. Towolawi

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Open access Nov 2026

GNG2–MRAS interaction regulates SHOC2-dependent RAF activation and MAPK signaling

Dysregulation of the mitogen-activated protein kinase (MAPK) signaling pathway is a hallmark of many human cancers and RASopathies. The SHOC2–MRAS–PP1Cα (SMP) holophosphatase complex is a crucial regulatory node of this pathway. It activates the MAPK pathway by dephosphorylating the inhibitory phosphoserine on RAF kina...

G. Navale, B. Towolawi, Colin Christoff et al. · 0 citations

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