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Open access Sep 2026

Herpesviridae Reactivation and Therapeutic Outcomes in Patients with Ulcerative Colitis Treated with Tofacitinib

Background: Ulcerative colitis (UC) is a chronic inflammatory bowel disease. Historically, anti-tumor necrosis factor (TNFα) agents have been the mainstay of biological therapy. Recently, Janus kinase inhibitors (JAK-I) have emerged as oral alternatives. However, despite their acknowledged efficacy, concerns remain reg...

Sivan Harnik, Naama Lang, S. Yehezkel et al. · 0 citations
Aug 2026

Long-lasting extracellular matrix modifications reshape intestinal stem cell fate and promote chronic inflammation.

Tissue regeneration is viewed as a return to homeostasis, but whether the extracellular matrix (ECM) reverts during recovery from gut inflammation is unclear. Using temporal multi-omics, biomechanical profiling, and spatial fate mapping in colitis models, we showed that colonic ECM underwent lasting pathological reprog...

Idan Adir, C. Sochen, S. Gelb et al. · 0 citations

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