Author

B. Vemparala

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Open access Sep 2026

Modeling how memory CD8 T cells can elicit post-treatment control of HIV infection

While most people living with HIV suffer progressive disease following cessation of antiretroviral therapy, a small fraction elicits lasting post-treatment control. Understanding the mechanisms underlying this control is key to devising effective HIV remission strategies. Although recent studies implicate memory CD8 T...

B. Vemparala, C. Passaes, D. Desjardins et al. · bioRxiv · 0 citations

Open access Aug 2026

SARS-CoV-2 Delta variant-specific ORF3a mutations destabilize lysosomal homeostasis to trigger lysosomal damage-mediated cell death

It is shown that variations in SARS-CoV-2 ORF3a correlate with the pathogenic potential of VOCs and drive Delta variant-specific lysosomal damage that activates inflammatory cell death and disrupts lysosomal homeostasis and triggers cell death.

Ayushi Amin Dey, Sanchita Mishra, Vigneshwar Reddy Ashireddygari et al. · Communications Biology · 0 citations