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Open access Oct 2026

Temporal trends and prognostic impact of comprehensive guideline-directed medical therapy in HFrEF: a 1-year follow-up from the KorHF III registry

Comprehensive guideline-directed medical therapy (GDMT) improves survival in heart failure with reduced ejection fraction (HFrEF). However, real-world implementation and its longitudinal impact on outcomes remain incompletely characterized. This study evaluated temporal trends in GDMT implementation and th...

S. Kim, B. Yoo, J. Son · 0 citations
Open access Aug 2026

Association of Poor Adherence to Guideline-Directed Medical Treatment With Adverse Events Including Fatal Arrhythmia in Heart Failure With Reduced Ejection Fraction: A Nationwide Cohort Analysis.

BACKGROUND AND OBJECTIVES Poor adherence to guideline-directed medical therapy (GDMT) in heart failure with reduced ejection fraction (HFrEF) correlates with increased risks of mortality and hospitalization. Whether it is associated with life-threatening ventricular arrhythmias (VA) remains unclear. We assessed GDMT ad...

Moojun Kim, D. Cho, Ji-Mi Choi et al. · 0 citations

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