Integrative transcriptomic and machine learning analysis identifies S100A8 as a key hub bridging peripheral inflammation and synaptic deficits in schizophrenia.
Schizophrenia (SCZ) involves immune dysregulation and synaptic deficits, yet the molecular link between peripheral inflammation and central synaptic pathology remains unclear. We integrated blood transcriptomes from four SCZ cohorts (478 samples: 245 patients, 233 controls) and validated findings in single-cell brain d...