Pathophysiology, Clinical Manifestations, and Pharmacological Management of Pruritus in Primary Biliary Cholangitis: A Systematic Review
Primary Biliary Cholangitis (PBC) is a chronic autoimmune cholestatic liver disease marked by the progressive destruction of small intrahepatic bile ducts. Chronic pruritus affects about 70-80% of patients, can greatly diminish quality of life, and does not present with primary skin lesions. Its pathogenesis is complic...