Balak Das Kurmi

Comprehensive exploration of biomass and biowaste based polymers covering synthesis characterization and applications

Biomass/biowaste-derived polymers are an advanced approach for the preparation of biodegradable and environmentally friendly polymers from renewable sources. This review focuses on methods for preparing, characterizing, and applying polymers derived from agricultural waste, animal waste, food leftovers, forestry residu...

Development and Characterization of β-Cyclodextrin and Methotrexate Inclusion Complex-Based Nanogel for the Management of Rheumatoid Arthritis

Next-Generation Genome Editing: Overcoming CRISPR-Cas9 Limitations with Prime Editing and PASTE Technology

CRISPR-Cas9 has transformed gene editing; however, it is based on doublestrand DNA breaks, which may result in unintentional mutations and structural alterations, thereby limiting its clinical translation. Instead of DSBs, new precision instruments, including prime editing, can be used to perform accurate search-an...

Doxorubicin-Postbiotic Transethosomes: Formulation and In Vitro Evaluation

The developed transethosomal system showed favorable physicochemical properties, sustained drug release, stability, antioxidant and antimicrobial activity, and significant cytotoxicity against melanoma cells, which support its potential as a multifunctional topical platform for localized melanoma therapy and provide a...

Recent strategies and approaches for the development of molecularly targeted nanomedicine.

This chapter highlights the role of targeting ligands, stimuli-responsive systems, and tumor microenvironment-specific strategies in enhancing therapeutic efficacy while minimizing adverse effects, emphasizing the potential of molecularly targeted nanomedicine to advance precision therapy and improve clinical outcomes.

Advances in quinazolin-4-one scaffolds in breast cancer therapy: emerging designs, mechanistic perspectives and SAR trends (2015-2025).

This review highlights the structure-activity relationship (SAR) of different quinazolinone derivatives along with their binding interactions which indicate that the electronic and lipophilic characteristics of substituents on different positions of the quinazolinone core significantly affect their activity in breast c...