The human genome encodes a wide variety of protein kinases that regulate multiple cellular functions. These enzymes play a crucial role in amplifying and propagating intracellular signals during signal transduction. Dysregulation of protein kinase signaling is associated with vascular diseases, inflammatory disorders,...
Rajwinder Kaur, D. K. Lang, Ankita Sood et al.· RSC Advances· 0 citations
In this study, nine derivatives of 3,10-dihydro-2
H
-1,3-oxazepino[7,6-
b
]indole (1–9), which combine two bioactive pharmacophoric cores, were synthesized and tested for antibacterial activity against five pathogenic bacterial strains. The resazurin-based microdilution plate method was used to determine minimum...
Mervat S. Sammor, Marwan M. Abu Halaweh, Khadeejha Al Abrouni et al.· Pharmacia· 0 citations
The synthesized benzoxazole hybrid compounds showed promising anticancer activity with acceptable ADMET properties; however, further structural optimization and mechanistic studies are needed to validate the molecular targets and improve safety and pharmacokinetic profiles.
Mahmoud A. Al-Sha'er, A. H. Abdullah, Almeqdad Y. Habashneh et al.· Chemistry Africa· 0 citations
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