Open access
Sep 2026
Dual targeting of CD244 and CD2 by a viral-immunoevasin-guided engineered CD48-Fc mutant for T- and NK-cell modulation
C5-Fc# is established as a rationally engineered dual-specificity inhibitor with translational potential for autoimmune diseases after disrupting NK- and T-cell conjugate formation and reducing CD244- and CD2-dependent cytotoxicity.
Olga Bautista-Cerecero, P. Hernández-Luis, Pablo Martínez-Vicente et al.
· Frontiers in Immunology · 0 citations