Aug 2026
Hepatocyte NAT10-mediated ac4C regulation contributes to TGFβ1-associated Kupffer cell -HSC communication in steatotic liver disease.
BACKGROUND AND OBJECTIVE Obesity and metabolic syndrome impose chronic lipotoxic stress on hepatocytes, contributing to macrophage reprogramming and fibrosis progression in steatotic liver disease. However, how soluble hepatocyte-derived factors regulate Kupffer cell-hepatic stellate cell (HSC) crosstalk remains unclea...
Miao-miao Zeng, Quan-Lin Guan, Yi-Chen Guo et al.
· Biochemical and Biophysical... · 0 citations