Author

Bao-Di Ma

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Open access Jul 2026

Computational Redesign of Aspartase from Escherichia coli and Its Catalytic Synthesis of β-Alanine

Aspartase from Escherichia coli (AspA) catalyzes the direct conversion of acrylic acid to β-alanine; however, its substrate specificity and low catalytic efficiency limit its broader application. We engineered an AspA mutant capable of efficiently catalyzing the amination of acrylic acid for β-alanine synthesis, using...

Long-Xian Li, Bao-Di Ma, Yi Xu · Catalysts · 0 citations