Author

Bao-Jun Zhang

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Aug 2026

ZFP335-MYBL2 transcriptional axis orchestrates Th17 cell differentiation and psoriatic inflammation.

T helper 17 (Th17) cell differentiation is governed by a complex transcriptional network centered on the lineage-specifying factor RORγt, accompanied by STAT3, IRF4, and SMAD2/3. However, the complete repertoire of transcriptional regulators controlling Il17a gene transcription and Th17 commitment remains incompletely...

Wen-Hua Li, Biao Yang, Ning Yuan et al. · Journal of Immunology · 0 citations

Review Aug 2026

Bap1-mediated deubiquitination determines immune tolerance and anti-tumor immunity via modulating eTreg cell differentiation and ferroptosis.

This work identifies the histone deubiquitinating enzyme Bap1 as a pivotal regulator of eTreg cell fate via its H2A deubiquitination activity to maintain immune tolerance and restrains antitumor immunity.

Hai-Yan Liu, Yan-Hong Su, Danni Chen et al. · Cell Death and Differentiati... · 0 citations