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Bao-Quan Ding

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Open access Sep 2026

Co-Assembled Mirror-Image DNA Nanostructure for Effective Alleviation of Acute Kidney Injury.

The high demand for acute kidney injury (AKI) therapy calls for the development of new therapeutics for renal management. Oxidative stress, coupled with excessive inflammation, is the main pathological mechanism for AKI. Specifically, complement component 5a (C5a) exacerbates the vicious cycle between oxidative stress...

Yiming Xie, Shuhui Yu, Yunfei Jiao et al. · 0 citations
Sep 2026

Branched DNA Nanoplatform-Based Multivalent PROTACs for Tumor Microenvironment-Responsive Degradation of Telomere-Binding Proteins in Tumor Therapy

Targeted protein degradation systems have been widely employed in biomedical applications. Herein, we report a branched DNA nanoplatform-based multivalent proteolysis-targeting chimera (PROTAC) for efficient degradation of telomeric repeat-binding factor proteins (TRF1/2) in vivo. In our design, a branched DNA-based...

Han-Yin Zhu, Xin-Tong Li, Hong Wang et al. · 0 citations
Review Aug 2026

Cell Surface Engineering with DNA Nanotechnology: From Molecular Design to Biological Application.

The recent progress is highlighted in biological applications of DNA-based cell surface engineering, including programming cell-cell interactions, biosensing of cellular microenvironment, regulation of signal transduction, and disease surveillance and treatment.

Min Xiong, Yiming Xie, Na Li et al. · 0 citations

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