The high demand for acute kidney injury (AKI) therapy calls for the development of new therapeutics for renal management. Oxidative stress, coupled with excessive inflammation, is the main pathological mechanism for AKI. Specifically, complement component 5a (C5a) exacerbates the vicious cycle between oxidative stress...
Targeted protein degradation systems have been widely employed in biomedical applications. Herein, we report a branched DNA nanoplatform-based multivalent proteolysis-targeting chimera (PROTAC) for efficient degradation of telomeric repeat-binding factor proteins (TRF1/2) in vivo. In our design, a branched DNA-based...
Han-Yin Zhu, Xin-Tong Li, Hong Wang et al.· Nano letters (Print)· 0 citations
The recent progress is highlighted in biological applications of DNA-based cell surface engineering, including programming cell-cell interactions, biosensing of cellular microenvironment, regulation of signal transduction, and disease surveillance and treatment.
Min Xiong, Yiming Xie, Na Li et al.· Journal of Physical Chemistr...· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.