Integrated transcriptomic and experimental analyses identify SRPK1/SRSF1 as a therapeutically relevant splicing regulatory Axis in pulmonary fibrosis.
Idiopathic pulmonary fibrosis (IPF) is characterized by progressive extracellular matrix deposition and irreversible distortion of lung architecture. We hypothesized that aberrant kinase-dependent splicing may contribute to IPF pathogenesis and offer an avenue for therapeutic intervention. We therefore analyzed multipl...