Jul 2026
Discovery of highly potent and selective VAV1 molecular glue degraders for the treatment of inflammatory disorders 2332299
This work has discovered potent and selective VAV1 molecular glue degraders with favorable in vivo pharmacokinetic and pharmacodynamic properties and aims to explore their potential in treating a range of inflammatory conditions, including neuroinflammation.
Li Xing, Jingbing Wang, Wei Zhu et al.
· Journal of Immunology · 0 citations