Discovery of 2-Cinnamoylbenzimidazoles as Novel Insect and Fungal Trehalose-6-Phosphate Phosphatase Inhibitors
Trehalose-6-phosphate phosphatase (TPP), a key enzyme in trehalose biosynthesis, represents a promising target for pest and fungal control due to the absence of TPP in higher animals. However, few TPP inhibitors have been reported, and broad-spectrum agents targeting both insects and fungi remain scarce. In this stud...