Citrulline alleviates oxidative stress-induced pyroptosis of nucleus pulposus cells via inhibiting the assembly of NLRP3 inflammasome.
Intervertebral disc degeneration (IVDD) is a significant contributor to low back pain and is associated with oxidative stress-induced pyroptosis of nucleus pulposus (NP) cell. Citrulline, a non-essential amino acid integral to the urea cycle and nitric oxide synthesis, plays an essential role in maintaining intracellul...