Barbora Šalovská

Baseline cellular state shapes the molecular impact of mutant KRAS alleles in reconstituted pancreatic cancer cells.

KRAS is mutated in over 90% of pancreatic ductal adenocarcinomas (PDAC), where hotspot alterations in codons 12, 13, and 61 drive tumor initiation and progression. Although distinct biochemical properties have been described for individual KRAS mutants, whether they generate unique allele-specific signaling programs in...