Bart de Laat

Stress-induced dorsal striatal dopamine release is associated with changes in functional connectivity to the prefrontal cortex in nicotine-dependent individuals—a preliminary report

The neural mechanism linking stress to addiction pathophysiology remains unclear. A proposed pathway involves stress-induced dopamine (DA) transmission impairing inhibitory control, leading to relapse. Lipopolysaccharide (LPS), a biological stressor inducing systemic inflammation, amplifies DA release. Our prior st...