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Author

Basil J. Greber

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Open access Nov 2026

Molecular basis of Cyclin B1-CDK1 recruitment by MAD1

The interaction between Cyclin B1-CDK1 and MAD1 recruits kinase activity to the nuclear pore complex and kinetochore corona to sustain spindle assembly checkpoint (SAC) signaling. Here, we characterize a short linear motif (SLiM) within MAD1 that mediates its interaction with Cyclin B1. This SLiM peptide is specific fo...

Mihkel Örd, N. de Martín Garrido, Matthew J. Winters et al. · 0 citations
Open access Oct 2026

Cryo-tides: synthetic peptides for cryo-EM grid preparation of multi-subunit protein complexes sensitive to the air-water interface

Cryogenic electron microscopy (cryo-EM) has enabled rapid progress in structural biology throughout the last decade. However, cryo-EM sample preparation still represents a major bottleneck in high-resolution structure determination. Many proteins and macromolecular complexes interact with the air-water interface during...

Rose Young, Amy J. S. McGeoch, M. Jessop et al. · 0 citations
Open access Jul 2026

Visualization of stepwise derepression of TFIIH in global genome nucleotide excision repair

High-resolution structures of three NER intermediates are determined that visualize how TFIIH arrives at sites of DNA damage in an autoinhibited state and how autoinhibition is released via previously undescribed intermediates, contributing to a mechanistic understanding of human DNA repair.

Natàlia de Martín Garrido, Callum A. F. Haste, Junjie Feng et al. · 0 citations

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