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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

Bassam G. Haddad

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Open access Aug 2026

Multi-ion permeation and dynamic conductance modulation in connexin gap junction channels

Gap junction channels formed by connexins mediate direct intercellular communication and are essential for electrical signaling and tissue homeostasis. Despite their large, solvent-accessible pores, connexin channels exhibit distinct conductance, selectivity, and rectification properties, but the molecular mechanisms u...

Bassam G. Haddad, Daniel M. Zuckerman, S. Reichow · 0 citations
Open access Aug 2026

The ZBTB16/CUL3/ROC1 ubiquitin ligase drives the degradation of pathogenic pendrin (SLC26A4) protein variants

A primary mechanism of SLC26A4 regulation in the inner ear and kidney and of SLC26A4 loss of function in Pendred syndrome and deafness DFNB4 is described and a atomistic model of the complete SLC26A4/ZBTB16/Cullin 3/RocI complex is provided in agreement with experimental results.

Florian Huber, E. Bernardinelli, Bassam G. Haddad et al. · 0 citations

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