Beate Nachtigall

Halogenated Tryptophans Improve Integrin αVβ6 Affinity of Cyclic RGD Peptides and Provide Handles for Late-Stage Derivatization.

A robust design for αVβ6-targeting functional probes for molecular imaging and fluorescence-guided tumor detection and an anthracenyl-functionalized derivative combines sub-nanomolar αVβ6 affinity with water solubility and intrinsic fluorescence, demonstrating that even bulky π-systems can be accommodated at discrete p...