Myeloid Suppressor Cells Drive HCC Invasiveness via the THBS1-SDC4 Pathway.
This study provides mechanistic insight into how M-MDSCs are activated within the HCC tumor microenvironment and subsequently drive tumor cell EMT through THBS1-SDC4 signaling, and indicates the THBS1-SDC4 axis may represent a therapeutically targetable pathway to restrain M-MDSC-mediated tumor aggressiveness and modul...