Open access
Aug 2026
Rational and computation-assisted engineering of a compact and efficient CRISPR-Cas12f genome editor.
It is demonstrated that integrating protein language model-assisted filtering with structure-guided rational design provides an effective strategy for engineering PspCas12f1 and may facilitate the optimization of additional compact CRISPR nucleases.
Jing-Tong Liu, Sheng-Zhou Wang, Bei Wang et al.
· Molecular Therapy · 0 citations