A programmable DNA circuit based on target recycling-assisted DNAzyme combined with elemental labeling ICP-MS for p21 mRNA detection.
The strand displacement reaction (SDR) has shown considerable potential in bioanalysis due to its enzyme-free nature, predictable base-pairing behavior and excellent programmability. Herein, we developed a programmable DNA circuit with SDR-mediated target recycling-assisted DNAzyme (TRDz) for dual signal amplification,...