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Benedict J. Leong

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Jul 2026

Abstract P106: SELECTIVE CYTOTOXICITY IN KRAS-MUTANT CANCER CELLS THROUGH COORDINATED STABILIZATION OF KRAS AND ITS UPSTREAM REGULATORS USING SMALL MOLECULE DRUG

Results suggest that C1-induced lethality involves coordinated stabilization of multiple upstream KRAS regulators, with GRB2 acting as one component that may amplify signalling in a mutant-specific context, a novel mechanistic axis of synthetic lethality in KRAS-driven cancers.

Benedict J. Leong, K. Iskandar, Liang Ying Yu et al. · 0 citations