Author

Benedikt Obermayer

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Open access Aug 2026

Kiosc: an integrated platform for managing bioinformatics data analysis containers

Background In many bioinformatic data analysis projects, it is convenient to visualize plots and results through an interactive web app or dashboard. These interactive reports can then be shared with customers, collaborators, or the general public. Publishing and sharing these apps is not straightforward, becoming espe...

Federico Marotta, Oliver Stolpe, Benedikt Obermayer et al. · bioRxiv · 0 citations

Open access Aug 2026

Translating multi-omics complexity into sparse prognostic biomarkers for multiple myeloma

Multiple myeloma (MM) exhibits profound molecular heterogeneity, yet current risk stratification relies on cytogenetics or single-omics signatures that often fail to capture cross-layer regulatory complexity. We re-analyzed a multi-omics dataset integrating copy-number, transcriptomic, proteomic, and phosphoproteomic d...

Benedikt Obermayer, M. Benary, J. Krönke et al. · bioRxiv · 0 citations

Aug 2026

Central Thyroid Hormone Deprivation Disrupts Cortical Cilia and Oligodendrocyte Lineage in an Allan–Herndon–Dudley Syndrome Mouse Model

These findings provide the first single-cell–level cortical map of AHDS brain pathology, revealing cilia defects, excitation–inhibition imbalance, differing pseudotime trajectories in glutamatergic neuronal populations and altered oligodendrocyte maturation, with actionable candidate genes such as Lama2, Litaf, and Dcc...

Anna Molenaar, Ekta Pathak, Miriam Bernecker et al. · Thyroid · 0 citations