Open access
Oct 2026
Scn1a-mediated developmental regulation of prefrontal cortex plasticity and cognition.
OBJECTIVE The voltage-gated sodium channel Nav1.1, encoded by Scn1a, is essential for γ-aminobutyric acid (GABA)ergic function, and its alteration is associated with neurological disorders such as Dravet syndrome and Alzheimer's disease. We previously demonstrated that local Nav1.1 dysfunction in the medial prefrontal...
M. Riga, Mercedes Pérez-Fernández, Yuniesky Andrade-Talavera et al.
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