Benjamin A. Garcia

Integrator governs NF-κB dwell time on chromatin to drive inflammatory transcription

NF-κB must remain bound to chromatin long enough to activate innate immune genes, but what stabilizes this transcriptionally productive state is unknown. Here, we identify the Integrator complex as an essential determinant of NF-κB chromatin residence in mouse and human cells. Integrator associated with NF-κB and co-oc...