Author

Benjamin D. Greenbaum

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Open access Sep 2026

Neoantigen-reactive CD8+ T cell engagement marks exceptional survivors of pancreatic cancer

Pancreatic cancer (PC) is largely refractory to immune checkpoint blockade (ICB), although homologous recombination-deficient (HRD) tumors may derive benefit. In the POLAR trial of maintenance pembrolizumab plus olaparib after platinum-based chemotherapy for metastatic PC, responses remained heterogeneous. To define de...

M. Hilmi, J. Schoenfeld, Wilson H. McKerrow et al. · bioRxiv · 0 citations

Review Open access Jul 2026

Associative memory plays a role in ER-1α positive breast cancers.

This perspective brings together multiple observations concerning the regulatory architecture and functional interactions of the TP53 gene and its isoforms to cooperate to maintain an open chromatin state in the P2 region in a manner reminiscent of a neural "associative memory" network.

Dan Lu, D. Hoyos, Ning Yao et al. · Cell Death and Differentiati... · 0 citations