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Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

Author

Benjamin F. Cravatt

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Open access Aug 2026

Activity-based profiling of primary brain cells identifies covalent allosteric modulators of HCN channels

Chemical proteomics can provide global portraits of small molecule-protein interactions in native biological systems. Such ligandability maps have, however, been mostly restricted to readily accessible cell lines and primary immune cells. Here, we describe an activity-based protein profiling (ABPP) strategy for mapping...

Elva Ye, Alberto Russo, Roberta Castelli et al. · 0 citations
Open access Jul 2026

ESCAPE: assigning site-specific activity to covalent ligands in cells by prime editing

ESAPE (Endogenous Site-specific Competition Assays using Prime Editors using Prime Editors), a platform for the site-resolved functional analysis of covalent ligands in cells, identifies multiple covalent ligand-protein interactions that impair cancer cell growth.

Jason Tse, William R. Brothers, Rachel E. Hayward et al. · 0 citations

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