Author

Benjamin G. Bitler

2 papers indexed here

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Open access Sep 2026

Targeting MAT2A-S-adenosylmethionine (SAM) Axis Attenuates DNA Damage Response and Cancer Stemness to Increase Platinum Sensitivity in Ovarian Cancer

Metabolic and epigenetic reprogramming drives development of platinum resistance and disease recurrence in high-grade serous ovarian cancer (HGSC), a major clinical challenge in the field. S-adenosylmethionine (SAM) is the universal methyl group donor, synthesized by methionine adenosyltransferase 2A (MAT2A) from methi...

Shu Zhang, Zhen Fu, Yan-Chi Zhou et al. · bioRxiv · 0 citations

Jul 2026

Targeting p300 Reverses Acidic Microenvironment-Induced PARP Inhibitor Resistance.

Poly(ADP-ribose) polymerase inhibitors (PARPi) are a first-line treatment for epithelial ovarian cancer (EOC) patients, but the development of resistance limits long-term therapeutic efficacy. Tumor acidosis is a hallmark of the tumor microenvironment that has been shown to promote resistance to cancer therapies, sugge...

Kaixin Cheng, Hao Nie, Wei Zhou et al. · Cancer Research · 0 citations