Author

Benjamin Izar

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Open access Sep 2026

9 CD8+ T Cells and Clinical Outcomes from the CYTO Reductive Surgery in Kidney Cancer Plus Immunotherapy and Targeted Kinase Inhibition (Cyto-KIK) Trial

Abstract Background In 2020, CheckMate9ER established cabozantinib (cabo) and nivolumab (nivo) as a first-line treatment regimen for metastatic clear cell renal cell carcinoma (mccRCC). Despite recent therapeutic advancements in mccRCC, only about 10-15% of patients will achieve a complete response (CR) to current firs...

K. Runcie, Calvin Park, M. Ornstein et al. · The Oncologist · 0 citations

Open access Jul 2026

Linking zygosity and allelic balance to phenotype with programmable heterozygous editing and allele-specific single-cell RNA sequencing 2307550

An innovative CRISPR-based editing system in primary human T cells is harnessed to engineer heterozygous variants across CARD11, a key regulator of immune signaling, in which heterozygous variants cause diverse IEI with variable penetrance.

Zachary H. Walsh, C. Frangieh, Shudipto Wahed et al. · Journal of Immunology · 0 citations