Open access
Aug 2026
Frailty before chronic disease: multisystem physiological differences in middle-aged adults from the UK Biobank.
Frailty in disease-free middle-aged adults was associated with multisystem physiological alterations resembling those observed in older and multimorbid populations, suggesting early physiological dysregulation preceding clinically manifest chronic disease.
Paula Stürmer, G. C. Silva, A. Fayosse et al.
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