Abstract As one of the most abundant and diverse post-translational modifications in biology, glycosylation has a significant influence on the functions of proteins in health and disease. To untangle the complexity of glycan biosynthetic pathways, the process of studying glycosylation has been expedited by specialised,...
Freya Hoddle, Sophie D. Schmidt, Sandhya Sridhar et al.· Biochemical Journal· 0 citations
Glycans impact every aspect of physiology. Despite the rapid increase in relevance and translational potential, there remains a lack of tools for studying glycosylation in vivo. Here, we present FlyMOE, a chemical-genetic platform for targeted glycoprotein profiling in Drosophila melanogaster. Transgenic flies are equi...
Sophie D. Schmidt, Cyrille Alexandre, Lucia Di Vagno et al.· bioRxiv· 0 citations
A new paradigm for the evolutionary drivers of haemagglutinin is presented, where reduced sialic acid binding can serve as an advantage for escape from host barriers and antivirals.
K. Sukhova, Jia-Yun Yang, Antonio di Maio et al.· bioRxiv· 0 citations
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