Effects of hydroxytyrosol on ISM-1, PODXL, p-mTOR, and p-AKT protein expression and 8-OHdG levels in doxorubicin-associated cardiac injury
Doxorubicin (DOXO) is an effective chemotherapeutic agent used in various malignancies, but its clinical use is limited by cardiotoxicity. Hydroxytyrosol (HT), a natural polyphenol in olive oil, has strong antioxidant and anti-inflammatory properties with potential cardioprotective effects. However, whether HT mo...