Transcriptomic Characterization of TCR-NK Cells Reveals Challenges Associated with CD3ζ Overexpression.
Objective TCR-engineered NK cells represent a promising strategy for targeting intracellular tumor antigens while overcoming the risk of TCR alpha/beta chain mispairing inherent to TCR-engineered T cells. Previous work showed that CD3ζ overexpression in TCR-NK cells did not improve antigen-specific cytotoxicity and ins...