Engineering Teriflunomide Solid Lipid Nanoparticles via Response Surface Methodology: Formulation Optimization and In vitro Performance Evaluation
Objective: Multiple sclerosis is a chronic inflammatory disorder of the central nervous system, commonly managed with Teriflunomide, a poorly water-soluble BCS Class II drug. The present study was designed to develop and optimize Teriflunomide-loaded solid lipid nanoparticles (TFE-SLNs) to improve its solubility and dr...