Hexokinase-2 moonlights as a suppressor of STING-mediated innate immunity.
Metabolic enzymes are increasingly recognized for "moonlighting" functions beyond their primary metabolic roles. While such non-canonical activities are well characterized in cancer biology, their roles in innate immunity remain poorly defined. Here, we show that Hexokinase II (HK2), a rate-limiting enzyme of glycolysi...