Bi-Ming Zhong

Engineering Escherichia coli for high-titer de novo biosynthesis of the N-nucleoside antibiotic Angustmycin A

Angustmycin A (also known as guvermectin) is a rare N-nucleoside antibiotic with broad-spectrum antimicrobial activity and registered agricultural use as a plant growth-promoting biochemical pesticide. Native Streptomyces producers remain the primary production source, but their slow growth, long fermentation...