Author

Bi-Xue Xu

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Open access Jul 2026

A trifluoromethyl quinazoline inhibits hepatocellular carcinoma proliferation through HDAC1 binding and multi-target mechanisms

KZL-064 is identified, a 2-trifluoromethyl-4-aminoquinazoline derivative, which markedly inhibits HCC cell proliferation, migration, and invasion, induces apoptosis and G2/M arrest, and oral administration achieves tumor suppression comparable to that of sorafenib without significant toxicity.

Shi-Mei Wang, Xudong Cui, Gang Yu et al. · iScience · 0 citations

Jul 2026

Design, synthesis, and anti-prostate cancer activity evaluation of novel thieno[2,3-b]pyridine derivatives as potential BLM helicase inhibitors.

Nine novel thieno[2,3-b]pyridine derivatives were rationally designed and synthesized based on a versatile key intermediate, representing a promising lead compound for the development of novel BLM-targeted anti-prostate cancer agents.

Wei Tu, Ningning Zan, Xinyu Liu et al. · Molecular diversity · 0 citations