Author

Bian-Xiao Cui

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Open access Sep 2026

GPCR antagonism via rewiring of receptor trafficking and degradation

G protein–coupled receptors (GPCRs) represent one of the most important yet incompletely addressed classes of therapeutic targets1. Here, we report a novel strategy for functional GPCR antagonism via bispecific antibody-mediated endocytosis and lysosomal degradation. GPCR-TfR1 targeting chimeras (GTACs) achieve potent...

Kaitlin Rhee, L. Shue, Akimasa Adachi et al. · Nature · 1 citation

Open access Aug 2026

Antibody Fc receptor CD16a mediates natural killer cell activation via mechanotransduction of piconewton forces

It is revealed that CD16a transduces piconewton forces and acts as a mechanosensor to facilitate NK activation, and it is demonstrated that CD16a force and the actin foci formation associated with it are essential for the phosphorylation of mechanosensitive adaptor Cas-L and signaling adaptor LAT, reshaping NK cell cyt...

Rong Ma, K. Garcia, Bian-Xiao Cui et al. · Science Advances · 0 citations

Open access Feb 2026

Antibody Fc receptor CD16a mediates natural killer cell activation via mechanotransduction of piconewton forces

Natural Killer(NK) cells eliminate target cells through antibody-dependent cell-mediated cytotoxicity(ADCC), initiated by CD16a(FcγRIIIa) recognizing the Fc region of antibodies bound to the target cell surface. While the recognition is considered to be driven by CD16a-Fc binding avidity, it fails to explain why Fc mul...

Rong Ma, K. Garcia, Bian-Xiao Cui et al. · bioRxiv · 0 citations